KCNQ Kanalak eta Parazetamola: Epilepsiaren Tratamendurako Aukera Bat? KCNQ Channels and Paracetamol: A Potential Treatment for Epilepsy

Abstract

KCNQ channels, also known as Kv7 channels, play a crucial role in regulating cellular excitability and maintaining membrane potential. These ion channels are essential for various physiological processes, such as the modulation of action potentials and neurotransmitter release. Recent studies have shed light on the interaction between KCNQ channels and NAPQI. NAPQI can enhance the current through these channels, potentially preventing neuronal hyperexcitability. This hyperexcitability, which is characteristic of certain forms of epilepsy, makes NAPQI a promising candidate for therapeutic intervention.

Understanding the mechanisms underlying the interaction between NAPQI and KCNQ channels is vital for deeply exploring their impact on neuronal function. Such knowledge opens new avenues for investigating strategies to regulate neuronal excitability. This review examines these interactions in detail, highlighting their importance for neuronal health and discussing potential opportunities for developing innovative treatments.

KEYWORDS: KCNQ channels, Kv7 channels, ion channels, neuronal excitability, membrane potential, action potentials, neurotransmitter release, NAPQI, neuronal hyperexcitability, epilepsy, therapeutic intervention, neuronal function, regulatory mechanisms, innovative treatments.