Kannabinoide berriak: segurtasun eta eraginkortasun terapeutikoaren bila

Abstract

Cannabis sativa plant contains non-psychoactive phytocannabinoids including cannabidiol, cannabigerol or Î"⁹-tetrahydrocannabivarin. Unlike classical cannabinoids (i.e Î"⁹-THC) most of these compounds bind with low affinity to cannabinoid receptors (CB), which seems to be the reason for their lack of psychoactive effect. Preliminary studies performed in humans and animals demonstrated that these cannabinoids have therapeutic properties. Different targets and mechanisms have been proposed to explain their effects such as activation of serotonergic receptors or modulation of different enzymes.