Click erreakzioa erabiliz aktibitate biologikoa erakusten duten sistema polimerikoen garapena

Abstract

In recent years, surgical implant procedures have become common strategies to restore the function of affected traumatological injuries. These implants placement requires the administration of antibiotic due to the possible presence of bacteria or other microorganism. Bacteria, normally adsorbed on the implant surface forming an adherent biofilm which exhibits increased protection from host defenses and improves resistance to antibiotic treatments. Therefore, medical devices with intrinsic antibacterial properties are highly desirable. However, the incorporation of antibiotics on the material is not easy to design due to additional structural restrictions that may compromise the bioactivity of these drugs. Thus, we considered the "click" reaction could be an excellent methodology for the conjugation of complex organic structures on the surface of many materials, since it can be carried out in water or physiological-like conditions at room temperature and product can be obtained in practically quantitative yield.