Luminiszentzia, baliabide aproposa ioien eta biomolekulen presentzia agerian jartzeko

Abstract

An efficient and high-resolution sensing of biomolecules and ions is of paramount relevance in biomedicine not only to monitor biochemical processes, but also to unravel the underlying mechanisms in diseases and find new drugs against them. Between the tested approaches to this aim, luminescence outstands as a suitable tool to gather such chemical information as an analytical signal, endowed with high sensitivity and specificity. The change of the fluorescence signal allows the visualization of the target molecules and its quantification as well. Therefore, fluorescent sensor can be developed applying dye chemistry, after anchoring a suitable receptor to a given chromophore. Herein, we disclose key guidelines to take into account in the design of such sensors. As a matter of fact, hereafter, we describe two BODIPY fluorophores based sensors to detect cations and amino acids. The monitorization is carried out following the change of the fluorescence efficiency and colour, respectively, being both of them properties easily visualized by the naked eye.