Antibiotikodun Lipido Solidozko Nanopartikulak bakterioen aurkako eraginkortasuna hobetzeko

Abstract

Antibiotic resistant bacteria are a global threat because they can contribute to the loss of the efficiency of actual therapies against infectious diseases. Maintenance of the efficiency of antibacterial drugs is crucial to overcome this problem and loading antibiotics into drug delivery systems can be a possible solution because they can improve drug efficiency and delay resistance emergence. Among all drug delivery systems, Solid Lipid Nanoparticles present optimal characteristics because apart from improving drug solubility, permeability, drug-release kinetics and stability they also help reducing drug toxicity. Solid Lipid Nanoparticles are composed of a solid lipid matrix surrounded by a surfactant monolayer that can be obtained using physiologic molecules. In order to obtain efficient drug delivery systems, it is important to understand interactions between nanoparticles and biological systems. Therefore, correct Solid Lipid Nanoparticles synthesis and characterization methods are essential. In this work, materials, production and characterization methods for Solid Lipid Nanoparticles development have been described. Besides, the state of the art of antibiotic-loaded Solid Lipid Nanoparticles is described in order to highlight the advantages of applying Solid Lipid Nanoparticles to improve antibacterial efficacy of actual antibiotic therapies.