Zer dela-eta zahartzen gara?

Abstract

Aging is a natural human process that produce functional impairment. There are many hypothesis that argue human aging, among this hypothesis we can find the exhaustion of stem cells. Stem cells have renewal and differentiation capacity and the number of this cells is decreased with aging. Brain is one the most affected organ aging and the decrease of Neural Stem Cell (NSC), reduce neuronal regeneration provoking cognitive decline. Neurogenesis occur in specific niches of the brain, in the subventricular zone and in the dentate gyrus of the hippocampus. Recent studies have demonstrate that this neurogenesis occur not only in the childhood but also during aging so it is really important to investigate how to maintain neural stem cell function during aging to reduce cognitive outcomes.