Disruptore endokrinoek eragiten al dute endometriosian? Berrikuspen sistematikoa

Abstract

Endometriosis (EM) is a highly prevalent disease that can cause disability and infertility among women. However, the factors influencing its pathophysiology have not yet been elucidated. In recent years, published studies suggest that exposure to environmental endocrine disruptors (EDCs) may contribute to EMs, and to identify the current evidence, the aim of this work is to carry out a systematic review. For this purpose, using the PRISMA methodology, a bibliographic search of studies on exposure to EDCs and EMs between 2012-2022 was carried out in the PubMed, ScienceDirect and Scopus databases. A total of 26 articles that met the inclusion criteria were identified. Most studies reported a positive association between at least one DE and EMs. In the case of BPA, a positive association was found in five out of seven articles, in the case of benzophenones in two out of three, and in all of the studies involving PFAS. Parabens and organophosphate pesticides were studied in only one article and showed a positive association. On the other hand, the results for phthalates and metals in general have been contradictory. In the case of Pb, it is possible that it is a risk factor only at low levels. The results clearly show that there are still few studies investigating the effect of exposure to EDCs on EMs. Although some studies suggest a relationship between certain EDCs and EM, due to bias problems and methodological differences between them, there is no strong epidemiological evidence. Further research is needed to examine the effect of exposure to the studied EDCs on EMs and to elucidate the mechanisms involved.