Atzoko baliabideak, biharko osasuna: ardo-hondakinak eta kannabisa

Abstract

This thesis was divided in two lines of research. On the one hand, supercritical fluid extraction was successfully applied to a sequential fractionation of fatty acids and polyphenols from wine wastes. Unfortunately, polyphenols have poor long-term stability and poor bioavailability, so they were microencapsulated. On the other hand, 3 different studies were done around medical use of cannabis. Firstly, in order to correlate plants with their physiological effects, an analysis method was developed to establish the cannabinoid fingerprinting of different cannabis plants. A method for the quantification of major cannabinoids and their metabolites in human urine and plasma was also developed. Finally, in order to optimize the production of bioactive compounds, the evolution of cannabinoid and terpene content of different chemotype plants during their growth was studied.