“Ingurunea nolakoa, neurogarapena halakoa”: burmuinetik eratorritako faktore neurotrofikoaren (BDNF) eragina fetu garaitik nerabezaro arte

Abstract

Neurodevelopment is defined as an orderly, dynamic and adaptive sequence of changes that begin in the embryonic stage and last, at least, until adolescence. During this period, the evolution of brain development takes place through the interaction between genetic factors and environmental influences. It has been shown that experiences at critical stages, such as pregnancy and childhood, may alter the structure and function of the brain through epigenetic mechanisms, thereby affecting the vulnerability of disorders. A neurotrophic that is sensitive to environmental factors and also plays an essential role in neurodevelopment is brain-derived neurotrophic factor (BDNF). Since adequate levels of BDNF are necessary for proper neurodevelopment, possible changes may lead to the abnormal functioning of certain brain areas, increasing the vulnerability of neuropsychiatric disorders. The aim of this work is therefore to identify the various factors affecting neurodevelopment during pregnancy,