Animalia-esperimentazioaren alborapen arriskua: SYRCLE RoB nahikoa al da?

Abstract

Random clinical trials have been considered the gold standard of clinical research. However, errors in design, behavior, analysis, or publication of results may lead to the misestimation of the actual impact of the intervention. This misestimation in called bias. In order to measure the reach of the bias, several tools, such as the Jadad scale or checklists, have been developed over time. In 2005, the Cochrane Collaboration, with the intent of changing the paradigm of these tools, published the Cochrane RoB (Risk of Bias) too, which was designed to be used in randomized clinical trials, and thus, with humans in mind. Nevertheless, animal experimentation is still indispensable in many areas, including basic and medical research. As a result, the SYRCLE organization proposed an adaptation of the Cochrane RoB in 2013 to make it viable in the field of animal experimentation. In this work, we conducted an analysis to measure the usefulness of SYRCLE’s adaptation using a sample of PubMed database articles. We also suggest a tool for measuring the usefulness of any risk of bias assessment tools, designated PROBATES.